Nature research paper: Inflammasome activation in infected macrophages drives COVID-19 pathology
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine production, viral RNA, and sustained interferon response all of which are recapitulated and required for pathology in the SARS-CoV-2 infected MISTRG6-hACE2 humanized mouse model of COVID-19 with a human immune systemor the downstream IFN stimulated cascade with anti-IFNAR2in the chronic stages of disease attenuated the overactive immune-inflammatory response, especially inflammatory macrophages.
Esen Sefik, Rihao Qu, Eleanna Kaffe, Haris Mirza, Jun Zhao, J. Richard Brewer, Ailin Han, Holly R. Steach, Benjamin Israelow, Holly N. Blackburn, Sofia Velazquez, Y. Grace Chen, Akiko Iwasaki, Eric Meffre, Craig B. Wilen & Richard A.
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