Blood donations will always be important.
run by NHS Blood and Transplant, which is looking to see how long lab-grown cells last in the body compared with donated blood cells. The trial will enroll at least 10 people, and each will get a few teaspoons of the manufactured blood. A few months later, they’ll be injected with the same amount of donated blood so researchers can compare their lifespans in the body.
If lab-grown cells do last longer in the body, it could mean people who need regular blood transfusions wouldn’t need them as often. That’d be impressive in and of itself. But the trial also lays the groundwork for an even bigger step: creating lab-grown blood for rare blood types that often aren’t found in donations.
For example, some people with sickle cell disease — a blood disorder that requires regular transfusions — develop antibodies against certain proteins on some donor blood cells. If that happens, they can’t receive blood with those proteins. Research teams could theoretically use the techniques pioneered in this trial to produce lab-grown blood without the problematic proteins.up production to create the amount of blood doctors would need for clinical use.
“The need for normal blood donations to provide the vast majority of blood will remain. But the potential for this work to benefit hard to transfuse patients is very significant,” Shah said.
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