News & Views: In large B cell lymphomas, immune features of the TME predict clinical outcomes after CARTtherapy; Joshua Brody &Theodora Anagnostou IcahnMountSinai discuss the latest data and clinical implications. joshuabrodyMD and TheodoraAnagno1
Chimeric antigen receptor T cells entered clinical trials over a decade ago and have shown unprecedented efficacy in patients with various hematologic malignancies.
The benefits of CAR T cell therapies have been greatest in patients with an aggressive type of B cell non-Hodgkin lymphoma known as diffuse large B cell lymphoma . However, modern miracles are limited, and unfortunately, ~60% of patients with DLBCL ultimately progress after anti-CD19 CAR T cell therapy
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