Improving research on diet and dementia KeckSchool_USC
to affect cognition."If it takes five to 10 years," said Yassine,"then studies that lasted for two years or less are not accurately reflecting the effect of the diet on cognition."
Genetic testing can also be an effective tool, according to Yassine, who studies apolipoprotein E4, or APOE4, which is the strongest genetic risk factor for late onset Alzheimer's disease. He noted that people with this genetic variant respond differently to diet than non-carriers. Here, genetic testing can improve the quality of research with more personalized interventions.
They note that one strategy would be to design small, personalized trials that consider participants' genetic risk, quality of their diet, and analysis of their microbiome while utilizing biomarkers that reflect brain functions. Another approach involves designing large, pragmatic electronic health trials using mobile phones or tablets to collect data, aimed at people with dementia risk factors.
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