Immune response after mild COVID ImmuneResponse Coronavirus Disease COVID pandemic Tcell medrxivpreprint UniJena LeibnizHKI
Various studies have reported the impact of medium and severe coronavirus disease 2019 cases on hospitalizations and related mortalities. However, more research is required to understand the effect of mild COVID-19 on antibody responses more than six months following the infection.
A total of 626 individuals were included in the first study round held in April 2020. Among these, 162 persons with a history of SARS-CoV-2 infection along with control participants who were matched based on gender and age were invited to participate in the second and third rounds of the study. A total of 146 participants were a part of the second visit held in October 2020, while 224 participated in the third visit held in April 2021.
The team assessed SARS-CoV-2 T cell-mediated immunity by analyzing spike protein-specific CD154+ 4-1BB+ cells found in TH cells. This immunity was determined by matching a cohort of 46 participants of the first and third visits, including 16 control persons and 30 infected patients.
Quantitative tests like EDI, Liaison, Maglumi Snibe, and Euroimmune showed that over the observation period of one year, there was a substantial reduction in the serum antibody concentrations. This decline in antibody concentrations varied among different time points and individual tests. A comparison of the reduced antibody concentrations between the EDI and the Euromimmune tests in the duration between 1.
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