itemprop=description content=Examine virus propagation within central nervous systems (CNSs) during systemic infection.
By Neha MathurOct 9 2023Reviewed by Lily Ramsey, LLM In a recent article in Science Immunology, researchers used the lymphocytic choriomeningitis virus model to examine virus propagation within central nervous systems during systemic infection.
Yet, systemic pathogens sometimes invade the CNS, leading to uncontrolled immune cell trafficking. Thus, it is crucial to explore how systemic pathogens breach CNS barriers. About the study In the present study, researchers tested the hypothesis that the CNS barriers of neonatal mice are more prone to systemic entry of microbes than young adult mice.
Further, they confirmed the depletion of targeted immune cells in the dura by flow cytometry analysis and immunofluorescence staining analysis. Moreover, adaptive immune cells played a minor protective role during this infection phase. However, inadequate establishment of this crucial immune barrier at the perisinus due to immaturity or their poor recruitment eventually facilitated LCMV entry to the CNS from the systemic circulation.
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