The treatments were highly popular earlier in the pandemic. One by one, they got knocked out by more convenient, less expensive treatment options, and new COVID variants.
Not everyone entirely agrees. Monoclonals are still useful, some doctors say, for treating a vulnerable population.
Monoclonal antibodies are lab-grown proteins that supplement your body's immune system – which, in most people, is naturally producing antibodies to hunt for possible threats all the time. Once a monoclonal antibody finds its soulmate — in the case of COVID, a specific part at the tip of the SARS-CoV-2 virus – it binds to the surface of the antigen. Then, it sends out signals to the immune system,"like hey, I've got a live one," Lowe says.
Companies have stopped bringing these monoclonals to market. The federal government stopped promising to buy them in quantity, making it a riskier bet for companies. is not susceptible to virus mutation because it targets the body's immune reaction to the virus, rather than the virus itself.There might still be hope for monoclonals. Drugmakers and researchers at government agencies are now retooling the strategy, looking for monoclonal antibodies that could last.at NIH."Now, there's awareness that we need to find antibodies that are likely to work against not just the [current version of the] coronavirus, but whatever may come.
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