How Jennifer Doudna&039;s Life Has Changed Since Discovering CRISPR 10 Years Ago
Doudna has distanced herself from the battle, aside from providing lab notebooks and other documentation to support Berkeley’s and University of Vienna’s case. But she appreciates that such legal questions are part of the baggage that comes with a ground-breaking discovery like CRISPR. Many people who meet her for the first time ask about it, she says, including students at Berkeley.
That will hopefully be the case in people as well, as more scientists find ways to use CRISPR directly inside patients’ bodies. In 2014, Doudna co-founded Intellia Therapeutics, and its scientists have tested a CRISPR-based intravenous treatment for transthyretin amyloidosis, a relatively rare disease involving the buildup of an abnormal form of a protein in organs and along nerves, causing damage to the heart and nervous system.
Solving agriculture’s biggest blights wasn’t part of Doudna’s initial agenda. But CRISPR can improve not just human health, but also the health of the planet. “It’s an unusual experience, being able to bridge all different disciplines of science—from plant biology and commercial agriculture to people working to treat human diseases—yet all of these problems are potentially treatable or can be addressed using CRISPR,” she says.
Years later, there still are no easy answers. In the controversial experiment in China, the twins’ father was HIV positive, and He edited a gene believed to contribute to resistance to HIV, in an effort to protect the children from the virus. But a Chinese court determined that He manipulated consent documents and questioned whether the parents were fully informed of the nature of the study; ultimately, He was jailed for violating medical regulations with his unorthodox experiment.
That could also apply to pandemics. When her lab researchers were desperate to continue their time-sensitive work during the early COVID-19 lockdowns in 2020, part of Doudna’s team at IGI developed a diagnostic COVID-19 test for all of Berkeley’s staff, students, and faculty in just three months. By September, the lab was federally certified to provide diagnostic tests and began testing frontline workers and underserved communities in the Bay Area.
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