How did snakes lose their limbs? Mass genome effort provides clues

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How did snakes lose their limbs? Mass genome effort provides clues
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An extensive effort to sequence the genomes of more than a dozen snake species has uncovered mutations that likely helped make their appendages vanish, as well as the DNA underlying other unusual traits.

Snakes are weirdos among vertebrates. Their bodies are typically too thin for more than one lung, they smell with their tongues, and—perhaps most importantly—they have no legs. Now, an extensive effort to sequence the genomes of more than a dozen snake species has uncovered mutations that likely helped make these appendages vanish, as well as the DNA underlying other unusual traits.

To conduct the study, Jia-Tang Li, a herpetologist at the Chengdu Institute of Biology at the Chinese Academy of Sciences, and colleagues sequenced the genomes of 14 species of snake in 12 families, a sample that spans 150 million years of snake evolution. They also looked at the genomes of 11 snake species that had previously been sequenced. With the new genomes and their analyses, Li has produced “an impressive paper with mind-blowing new resources,” Castoe says.

This “downregulation” also seems true of genes associated with the ability to hear high frequencies, but that genetic change may have led to the reptiles’ reconfigured ear bones, which make them exquisitely sensitive to vibrations. And to make all the organs fit, snakes are also missing two genes,, which typically guide an embryo’s development to make sure its body is symmetrical—with two lungs, for example.

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