The opioid epidemic is a public health emergency that claims the lives of more than 100 people in the United States every day on average, according to data from the National Center for Drug Abuse Statistics. Documented overdose deaths in 2021 reached nearly 108,000, the highest total number ever recorded in the U.S. More than 80,000 of those overdoses were opioid-related.
and can result in death; during an overdose, the body struggles to get the oxygen necessary to sustain the needs of the brain and other organs., such as counseling, care coordination, and therapy. Drugs used to treat opioid use disorder include opioid agonists and partial agonists , which help users by minimizing withdrawal and cravings. Buprenorphine is one notable partial agonist used in opioid addiction interventions.
People with opioid use disorder attempt to excessively replicate what is a natural process in the human body to suppress pain, allowing synthetic substances to bind to the receptors and trigger dopamine release. However, once they stop doing so, intense urges and withdrawal begin because the body is accustomed to artificially induced feelings of euphoria and pleasure.
After being absorbed sublingually, buprenorphine travels to the brain's mu-opioid receptors. Due to the high affinity of When buprenorphine molecules bind with mu-opioid receptors in the brain, they activate the receptors partially. If buprenorphine were a full agonist, it would produce a maximal response in a patient.without stimulating feelings of euphoria or causing respiratory depression to the extent abused exogenous opioids do.
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