Researcher Dhruv Sareen’s own stem cells are now orbiting the Earth. The mission? To test whether they’ll grow better in zero gravity.
At this point, the only stem cell-based products approved by the Food and Drug Administration contain blood-forming stem cells from umbilical cord blood for patients with blood disorders such as certain cases of lymphoma. There are no approved therapies using the kind of stem cells being sent to space or others derived from them, said Jeffrey Millman, a biomedical engineering expert at Washington University in St. Louis.
The issue? In large bioreactors, the cells need to be stirred vigorously or they clump or fall to the bottom of the tank, Millman said. The stress can cause most cells to die.The Cedars-Sinai team has sent up what are called induced pluripotent stem cells. Many scientists consider them the perfect starting materials for all sorts of personalized, cell-based treatments.
The work is designed to pave the way for more NASA-funded research. If they are able to figure out how to make billions of cells in orbit, Svendsen said, “the impact could be huge.”During the same cargo launch, researchers from the University of California, San Diego, sent blood stem cells to the space station, a repeat of an experiment they did last year. They want to find out if low Earth orbit induces faster aging in the cells, leading to problems that set the stage for precancerous changes.
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