The study is investigating whether high-dose IL-23 inhibition can target resident memory T cells and thereby induce long-term remission.
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The findings are interim results that pool the two doses of risankizumab . An evaluation of maintenance of efficacy with the 300-mg versus 600-mg doses and results of the skin biopsies will be presented at the 2024 annual meeting of the American Academy of Dermatology, he said. Patients who have not had recurrences are being followed up to week 100 .
"Resident memory T cells have been thought to be cells that are constrained to being resident in the tissue, and while that's largely true, there's more recent data showing that they actually can dedifferentiate and go back to the lymph node and then go back to the joint again," Dr. Ritchlin noted in an interview."So it's a more complicated story," but nonetheless targeting the cells is a concept worth exploring therapeutically.
During a discussion period, Dr. Blauvelt said that in a future iteration of the"knockout" study, he would like to evaluate risankizumab in patients with disease duration under 12 months. It may also be valuable to look not only at Trm cells, but more broadly at other elements of the tissue architecture before and after treatment.
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