The researchers made a breakthrough discovery of specific airway neurons in mice that alert the brain about the flu virus. A recent study in mice has revealed that a small population of airway neurons is responsible for alerting the brain about a flu infection The results help explain how dr
The findings shed light on the mechanism by which drugs such as ibuprofen and aspirin alleviate flu symptoms and suggest that the drugs may even improve survival rates.
“This study helps us begin to understand a basic mechanism of pathogen detection and how that’s related to the nervous system, which until now has been largely mysterious,” said senior author Stephen Liberles, professor of cell biology in the Blavatnik Institute at HMS and an investigator atThe findings also shed light on how nonsteroidal anti-inflammatory drugs such as ibuprofen and aspirin alleviate influenza symptoms.
Through a series of experiments in mice, first author Na-Ryum Bin, HMS research fellow in the Liberles lab, identified a small population of neurons embedded in the glossopharyngeal nerve, which runs from the throat to the brain. “We think that these neurons relay the information that there’s a pathogen there and initiate neural circuits that control the sickness response,” Liberles said.
The findings suggest an opportunity for improving flu treatment if scientists are able to develop drugs that target the additional pathway, the authors said.The study raises a number of questions that Liberles and colleagues are eager to investigate.
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