Pain that affects the gastrointestinal lining of mice may help to maintain a healthy gut microbiome.
at Harvard University and his colleagues wanted to better understand the role that pain neurons play in the gut. “If you look for pain fibres in the gut, you usually see them close to epithelial cells [which cover the gut lining], which suggests that they can talk to each other,” says Chiu.Without these neurons, the mice had thinner layers of mucus lining their guts compared with rodents that hadn’t been genetically modified.
Pain that affects the gut lining may be linked to mucus production for several reasons. “Some harmful products in the GI [gastrointestinal] tract, such as salmonella or, may require immediate attention,” he says. “You may want to coat the gut with mucus to protect it or the mucus could even facilitate wound healing, though this is speculative.”
In a laboratory experiment, the researchers looked at human goblet cells, finding that they also express high levels of the receptor for CGRP. “We think that human goblet cells could also respond to the same molecule from pain fibres,” says Chiu.
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