Donanemab has been linked to a 40% lower risk of progressing from mild cognitive impairment to mild dementia.
This is “just the opening chapter in a new era of molecular therapies for Alzheimer’s disease,” Dr. Gil Rabinovici, director of the UCSF Alzheimer’s Disease Research Center,“This will be a very important and meaningful drug,” said Dr. Daniel Skovronsky, chief scientific and medical officer at Lilly,Like Leqembi and Aduhelm, donanemab is a monoclonal antibody that attacks plaque in the brain that are made of a protein called amyloid.
The donanemab trial also found that the drug slowed cognitive decline by 35% compared with a placebo in people with low to intermediate levels of tau protein in the brain.And while Leqembi is meant to be taken for longer periods of time, people taking donanemab can have a fixed-duration dosing schedule, meaning patients can in some instances take it and stop.
“That’s a big difference than being prescribed a drug that you might have to take the rest of your life. And I think that could be exciting and important for patients.”Use of donanemab may be limited to people who have mild Alzheimer’s disease.Donanemab and the other new drugs have been linked to brain swelling and bleeding. Three people in the clinical trial of donanemab died from these side effects.
Additionally, people with more advanced cases of Alzheimer’s disease showed little to no benefit compared to those who took a placebo.
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