Genes expressed in the brain before birth may affect risk of childhood mental illness NatureNeuro
"We found those relationships to be more complex than we had imagined. For example, genetic risk for ADHD and depression were associated with a range of symptoms in children, not just those related to attention or mood," says co–senior author Joshua Roffman, MD, director of MGH's Early Brain Development Initiative."Thethat shape mental illness symptoms in kids differ from the ones that shape mental illness symptoms in adults.
The strongest genetic predictor for most mental health symptoms in ABCD participants was a new measure, developed by co–senior author and computational geneticist Phil H. Lee, Ph.D., and colleagues at the Mass General Center for Genomic Medicine, that indexes risk not for a single disorder, but rather for a constellation of developmental disorders.
Additional analyses of information from brain banks revealed that the genes in this set are expressed most strongly in the brain's cerebellum , and their expression in the cerebellum peaks before birth. Also, brain imaging data from the ABCD study indicated that children with psychiatric symptoms tended to have a slightly smaller cerebellum, perhaps a reflection of these genes' effects on cerebellar development during prenatal life.
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