Gene links exercise endurance, cold tolerance, and cellular maintenance in flies

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Gene links exercise endurance, cold tolerance, and cellular maintenance in flies
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As the days get shorter and chillier in the northern hemisphere, those who choose to work out in the mornings might find it harder to get up and running. A study in PNAS identifies a protein that, when missing, makes exercising in the cold that much harder—that is, at least in fruit flies.

As the days get shorter and chillier in the northern hemisphere, those who choose to work out in the mornings might find it harder to get up and running. A study inidentifies a protein that, when missing, makes exercising in the cold that much harder—that is, at least in fruit flies.

They were particularly interested in a physiological process called autophagy wherein damaged parts of cells are removed from the body. In screening the fly genome, they found a candidate for regulating the critical housekeeping procedure. Previous research has shown irisin to be an important hormone involved in producing musculoskeletal and other benefits ofLee's lab had an existing interest in exercise as a mild form of bodily stress.

, the investigators used a sort of fly cliff climber that capitalizes on the insect's instinct to climb upward out of a test tube.

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