In a preclinical study, the delivery of AAV-based genetherapy encoding GDNF in the brain prevented the return to alcohol use behaviors in a non-human primate model BriannaEGeorge vanlaar_victor SaraJonesLab OSUGeneTherapy
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.) The relationship between blood ethanol concentrations collected during the final week of the OAB and corresponding alcohol intakes recorded at timing of sampling for each subject as identified by drinking panel each was assigned , with the dashed horizontal line demarcating 80 mg/dl .
Extended Data Fig. 3 Individual Monthly Ethanol intakes and BECs, and Table of Day 1 Reintroduction Statistics.) Monthly individual subject means of daily alcohol intakes across each of the six alcohol reintroduction periods .) Table values and statistics of ethanol drinking patterns during each alcohol reintroduction onset as a factor of AAV2-hGDNF treatment. All values represent the mean ± SEM of each treatment .
Extended Data Fig. 4 Effects of AAV2-hGDNF on food and water intake, weight, and sensorimotor tasks in macaques.) Monthly averages of subject weight shown by group from the last month of OAB and during alcohol reintroduction phases R1 through R6 .) Monthly averages of subject water intake shown by group from the last month of OAB and during alcohol reintroduction phases R1 through R6 .
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