Prescription folic acid, a synthetic form of vitamin B9, may provide a safe and effective approach for decreasing suicidal ideation, new research suggests.
Results showed no association between cyanocobalamin and suicidal events in the adjusted analysis or unadjusted analysis .
Another sensitivity analysis showed every additional month of treatment was associated with a 5% reduction in the suicidal event rate. The new results"are so provocative that they really mandate the need for a well-controlled randomized controlled trial of folic acid and suicide events," possibly in a high-risk population such as veterans, he noted.
As for study limitations, the investigators note that this study was observational, so there could be selection effects. And using claims data likely underrepresented the number of suicidal events because of incomplete reporting. As the researchers point out, the rate of suicidal events in this study was much lower than the national rate.
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