Flawed body of research indicates true 'long COVID' risk likely exaggerated, says new study

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Flawed body of research indicates true 'long COVID' risk likely exaggerated, says new study
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Overly broad definitions, a lack of appropriate, or any, comparison groups, among other things, in studies looking at the incidence, prevalence, and control of the condition—epidemiology—have distorted the risks, say the researchers.

This is further compounded by inclusion of poorly conducted studies into systematic reviews and pooled data analyses that end up overstating the risk yet again, they add.care spending; misdiagnoses; and diversion of funds from those who really do have other long term conditions secondary to COVID-19 infection, suggest the researchers.

None of the working definitions of"long COVID" used by influential health bodies, such as the US Centers for Disease Control and Prevention, the World Health Organization, the UK National Institute for Health and Care Excellence , Scottish Intercollegiate Guidelines Network , and the Royal College of General Practitioners requires aNot only should comparator groups be included in long COVID studies, when they often aren't, but they should also be properly matched to cases, ideally...

This is known as sampling bias, which occurs when certain members of a population have a higher probability of being included in a study sample than others, potentially limiting the generalizability of a study's findings, explain the researchers. While the results of high quality population studies on long COVID in adults and children have been reassuring, they point out, the body of research"is replete with studies with critical biases" they add, setting out common pitfalls.

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