Long-term use of omega-3 fish oil supplements yields no net benefit for preventing depression or boosting mood, new research suggests.
For many years, experts have recommended omega-3 supplements for depression in some high-risk patients, Okereke says, but there are no established guidelines for its use.
The study enrolled 18,353 older adults . Of these, 16,657 were at risk for incident depression, defined as having no previous history of depression; and 1,696 were at risk for recurrent depression, defined as having a history of depression but not having undergone treatment for depression within the past 2 years.
Roughly half the participants were randomly assigned to receive omega-3 fatty acids and the other half to a placebo for an average of 5.3 years.
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