First pig-to-human cardiac transplant alters heart's electrical signals Heart Transplant Cardiology Genes Research Xenograft American_Heart UofMaryland
Xenotransplantation is the procedure of transplantation/implantation into a human of organs from non-human animal sources. The first pig-to-human heart xenograft was transplanted in January 2022 at the University of Maryland. The recipient survived for 61 days after receiving the xenograft. Research efforts have been underway for this xenotransplantation for over three decades.
Study: EKG Appearance and Evolution of Baseline EKG-Characteristics in the Worldwide First Genetically Modified Porcine-to-Human Xenotransplant . Image Copyright: American Heart Association Related StoriesThe ECG parameters of the “accepted pig heart transplant in the ‘pig body’” show short PR and QT intervals and short QRS . However, the first ECG of the pig-to-human heart xenotransplant showed a relatively longer PR interval of 190 ms, QT interval of 538 ms, and QRS duration of 138 ms.
Conclusions The ECG of the pig-to-human xenograft revealed prolongation of the typical ECG measures in the donor that included changes in depolarization and repolarization. It was a novel finding that the pig heart in the human showed different ECG parameters compared to the commonly observed findings for native pig hearts.
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