A study in BMCMedicine finds that family history of breast cancer is associated with an approximately twofold relative risk of breast cancer for Asian women. the same as seen in women of European ancestry, implying similar risk factors in both ancestries.
We searched for studies in three online databases including PubMed, Embase and Web of Science using Medical Subject Headings and Embase Subject Headings from the earliest publication date. Three search strategies were used: AND AND , AND AND and AND AND .
For the studies eligible for inclusion, we adopted the Risk of Bias in Non-randomised Studies of Exposure criteria [] to evaluate their quality on seven domains of bias: confounding, participant selection, exposure classification, departures from intended exposures, missing data, outcome measurement and reported result selection.
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Inflammation associated with lung function abnormalities in COVID-19 survivors - BMC Pulmonary MedicineBackground Activation of inflammatory pathways promotes organ dysfunction in COVID-19. Currently, there are reports describing lung function abnormalities in COVID-19 survivors; however, the biological mechanisms remain unknown. The aim of this study was to analyze the association between serum biomarkers collected during and following hospitalization and pulmonary function in COVID-19 survivors. Methods Patients recovering from severe COVID-19 were prospectively evaluated. Serum biomarkers were analyzed from admission to hospital, peak during hospitalization, and at the time of discharge. Pulmonary function was measured approximately 6 weeks after discharge. Results 100 patients (63% male) were included (age 48 years, SD ± 14) with 85% having at least one comorbidity. Patients with a restrictive spirometry pattern (n = 46) had greater inflammatory biomarkers compared to those with normal spirometry (n = 54) including peak Neutrophil-to-Lymphocyte ratio (NLR) value [9.3 (10.1) vs. 6.5 (6.6), median (IQR), p = 0.027] and NLR at hospital discharge [4.6 (2.9) vs. 3.2 (2.9) p = 0.005] and baseline C-reactive protein value [164.0 (147.0) vs. 106.5 (139.0) mg/dL, p = 0.083). Patients with an abnormal diffusing capacity (n = 35) had increased peak NLR [8.9 (5.9) vs. 5.6 (5.7) mg/L, p = 0.029]; baseline NLR [10.0 (19.0) vs. 4.0 (3.0) pg/ml, p = 0.002] and peak Troponin-T [10.0 (20.0) vs. 5.0 (5.0) pg/ml, p = 0.011] compared to patients with normal diffusing capacity (n = 42). Multivariable linear regression analysis identified predictors of restrictive spirometry and low diffusing capacity, but only accounted for a low degree of variance in pulmonary function outcome. Conclusion Overexpression of inflammatory biomarkers is associated with subsequent lung function abnormalities in patients recovered from severe COVID-19.
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Dietary protein intake and mortality among survivors of liver cirrhosis: a prospective cohort study - BMC GastroenterologyBackground Liver cirrhosis is a worldwide burden and is associated with poor clinical outcomes, including increased mortality. The beneficial effects of dietary modifications in reducing morbidity and mortality are inevitable. Aim The current study aimed to evaluate the potential association of dietary protein intake with the cirrhosis-related mortality. Methods In this cohort study, 121 ambulatory cirrhotic patients with at least 6 months of cirrhosis diagnosis were followed-up for 48 months. A 168-item validated food frequency questionnaire was used for dietary intake assessment. Total dietary protein was classified as dairy, vegetable and animal protein. We estimated crude and multivariable-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs), applying Cox proportional hazard analyses. Results After full adjustment for confounders, analyses showed that total (HR = 0.38, 95% CI = 0.2–1.1, p trend = 0.045) and dairy (HR = 0.38, 95% CI = 0.13–1.1, p trend = 0.046) protein intake was associated with a 62% lower risk of cirrhosis-related mortality. While a higher intake of animal protein was associated with a 3.8-fold increase in the risk of mortality in patients (HR = 3.8, 95% CI = 1.7–8.2, p trend = 0.035). Higher intake of vegetable protein was inversely but not significantly associated with mortality risk. Conclusion A comprehensive evaluation of the associations of dietary protein intake with cirrhosis-related mortality indicated that a higher intakes of total and dairy protein and a lower intakes of animal protein are associated with a reduced risk of mortality in cirrhotic patients.
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Bow crane collapse: Family angry over lack of answers three years onThe family of a woman who was killed when a crane collapsed on her house in July 2020 are still waiting for answers.
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The Kardashians Always Mix Business and Family—But the Cracks Are ShowingThere’s a cost to blending business opportunities and personal relationships, and it may never have been more apparent than it is in the current season of TheKardashians
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Co Down parents' tribute to baby boy on his second birthdayLast year, Pádraig's family raised over £8,000 in his memory
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The View's Kieren Webster takes mum along to TRNSMTKieren was keen to keep his nearest and dearest with him as he wandered around backstage
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