In total, 20 patients received the implants, then regained some or all of their vision after two years.
Aug. 11, 2022, 11:02 PM UTCTwenty people with diseased or damaged corneas had significant improvements in their vision after they received implants engineered out of protein from pigskin.
Not all patients experienced the same degree of improvement, however. The 12 Iranian patients wound up with an average visual acuity of 20/58 with glasses; functional vision is defined as 20/40 or better with lenses. To create the implant, Lagali and his team dissolved pig tissue to form a purified collagen solution. That was used to engineer a hydrogel that mimics the human cornea."We insert our material into this pocket to thicken the cornea and to reshape it so that it can restore the cornea’s function," Lagali said.
"Generally speaking, the body does handle pig tissues pretty well," said Dr. Uri Soiberman, an assistant professor of ophthalmology at Johns Hopkins Medicine who wasn't involved in the research. Usually, he added, rejections occur within a year of a transplant. "There’s always a risk for rejection of the human donor tissue because it contains foreign cells," he said."Our implant does not contain any cells ... so there’s a minimal risk of rejection."
The bioengineered implant"is used to replace the stroma, the central layer of the cornea,” he said."So that’s only for diseases where that part of the cornea plays some role in the pathology."
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