The intricate interactions between gut microbiota and drugs.
By Neha MathurOct 11 2023Reviewed by Lily Ramsey, LLM In a recent article published in Signal Transduction and Targeted Therapy, researchers extensively reviewed the intricate interactions between gut microbiota and drugs commonly used against several human systemic diseases, e.g., cancer, endocrine disorders, and cardiovascular diseases .
Introduction Gut microbiota, containing over 100 trillion microbes and five million genes, is increasingly considered a 'metabolic organ' or second genome. Causes of IVDR Several factors, including genetics, environment, age, gender, lifestyle, diseases, drugs, and gut microbiota influence IVDR. Some popular technologies to examine drugs and individual microbiota interactions are 16S and 18S ribosomal ribonucleic acid amplicons and whole-metagenome shotgun sequencing.
Similarly, laxatives changed the gut's dietary environment, reducing the availability of nutrients for good gut microbes. In general, antibiotics disrupt the natural ecosystem of the microbiota, leading to the overgrowth and colonization of pathogenic species and impacting drug safety.
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