A new drug may delay the onset of insulin-dependent Type 1 diabetes in those who are at high risk for the autoimmune disease, according to the results of a trial published in New England Journal of Medicine.
“This is the first time we have showed that immune therapy can delay progression to Type 1 diabetes,” Dr. Kevan Herold, a professor of Immunobiology and Internal Medicine at the Yale School of Medicine, and lead researcher for the trial, said in a statement.
Among the 32 people randomly assigned to the placebo group, half the participants developed insulin-dependent Type 1 diabetes within two years. By comparison, it took about four years for half of the group treated with teplizumab to develop Type 1 diabetes. The two most common side effects of teplizumab were a mild skin rash that went away by the end of the study and a temporary low level of a type of white blood cell called lymphocyte that also returned to normal, according to the authors.
“This study doesn’t answer the question if [teplizumab] prevents Type 1 diabetes entirely. We don’t know if the people who don’t have Type 1 diabetes yet will develop it later or never,” he said. “Having a science background, I knew we needed to do this to move science forward,” Cory Wirt told ABC News.
Pending FDA approval the drug could be on the market by the end of 2021, according to chief financial officer for Provention Bio, Andy Drechsler.
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