Evidence-based guidance is scant for clinicians treating patients who have monkeypox, and much of what is available is of low quality, according to a new systematic review.
An international research group of largely UK-based collaborators searched the medical literature for guidelines relating to the treatment and supportive care of patients with monkeypox.
Much of the advice was vague or contradictory, they found, with little to inform the care of higher-risk populations, such as children. The authors called for a rigorous framework to produce such guidelines before epidemics strike, including a way to quickly review and update guidance on the basis of new evidence.
"This is overall showing the lack of investment in monkeypox research before 2022, despite the fact that it's been actually circulating in these countries for a long time, with really high mortality, especially in DRC [Democratic Republic of the Congo]," said Müge Çevik, MD, a clinical lecturer in infectious diseases and medical virology at the University of St.
"On the one hand, we're lucky to have medications and vaccinations available for monkeypox," said Blumberg, who was not involved with the study."On the other hand, evidence-grade studies are lacking."The authors searched for guidelines relating to treatment and supportive care for patients with monkeypox, including a gray-literature search, in Arabic, English, French, German, Mandarin, Russian, and Spanish.
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