Drug slows Alzheimer’s but can it make a real difference?

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Drug slows Alzheimer’s but can it make a real difference?
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Lecanemab delayed patients’ worsening by about five months over the course of the 18-month study, according to a spokesperson with the drugmaker Eisai.

- An experimental Alzheimer’s drug modestly slowed the brain disease’s inevitable worsening — but the anxiously awaited new data leaves unclear how much difference that might make in people’s lives.that the drug lecanemab appeared to work, a badly needed bright spot after repeated disappointments in the quest for better treatments of the incurable disease.

The study’s key finding: Those given lecanemab declined more slowly, a difference of not quite half a point on that scale over the 18 months, concluded the research team led by Dr. Christopher van Dyck at Yale University. He said many researchers believe a meaningful improvement would require at least a difference of a full point on that 18-point scale.

“We all understand that this is not a cure and we’re all trying to really grasp what it means to slow Alzheimer’s, because this is a first,” Carrillo said. Also, two deaths have been publicly reported among lecanemab users who also were taking blood-thinning medications for other health problems. Eisai said Tuesday the deaths can’t be attributed to the Alzheimer’s drug.

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