Dormant bacteria count to wake up at the right time

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Dormant bacteria count to wake up at the right time
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Bacteria can shut down all of their functions for years to protect themselves. While they're dormant, they may count how often they sense nutrients and use that information to know when to wake up, scientists reported this week.

Microscopy image of several spores with their electrochemical potential color coded according to value. Image: Suel Lab – Kaito Kikuchi and Leticia Galera

Bacteria can shut down all of their functions for years to protect themselves. While they're dormant, they may count how often they sense nutrients and use that information to know when to wake up, scientists reported this week.The finding could be helpful in developing antibiotics for bacteria spores, like anthrax, that can be in dormant states that make them difficult to kill.

It could also provide clues about what life is capable of in extreme conditions — and help guide the search for life on Mars or other planets.Normally, cells receive signals when a gene is expressed or another biochemical reaction occurs. But bacteria spores are doing "literally nothing" when they are dormant, says Gürol Süel, a microbiologist at the University of California, San Diego.

From previous research, Süel and his colleagues knew the spores housed potassium ions. They thought the positively charged ions could be creating a pre-stored electrochemical potential in the spores — similar to a capacitor — that signaled they should wake up, or germinate.short pulses of nutrients, and measuring what happened as potassium ions left a spore's core and the electrical charge in the spore became more negative.

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