Does the time of day patients receive their COVID-19 vaccinations influence their clinical benefit? medrxivpreprint WUSTLmed YaleMed COVID19 coronavirus covid vaccinations vaccine vaccination SARSCoV2
By Pooja Toshniwal PahariaNov 7 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, researchers investigated whether the time of day at which coronavirus disease 2019 patients receive their severe acute respiratory syndrome coronavirus 2 vaccinations influences the vaccine effectiveness .
The study comprised 1,515,754 individuals aged ≥12 years with ≥1 time-stamped vaccination and no history of SARS-CoV-2 infections before the completion of the primary two-dose vaccinations. The team retrospectively analyzed MHS database EMRs covering the period between 19 December 2020 and 25 April 2022, including two SARS-CoV-2 infection peaks observed during the dominance of SARS-CoV-2 Delta and Omicron variants of concern .
Results Almost all of the study participants received COVID-19 BNT162b2 messenger ribonucleic acid vaccinations, and the remaining were vaccinated with mRNA-1273 vaccines. The majority of the individuals were vaccinated in a 12-hour period between 8 am and 8 pm. Among the vaccinees, 313,844 individuals, 292,278 individuals, and 236,348 individuals received D1 and D2 exclusively in the morning, afternoon, and evening, respectively.
Consistent results were obtained for the primary and booster vaccinees. A sinusoidal association was observed between SARS-CoV-2 vaccination timing and BTI risks, in accordance with a circadian rhythm in VE, with durations in the nine-hour to 15-hour range, dependent on the dose of vaccination.
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