Does leptin play a role in Parkinson’s disease? Leptin Parkinsons Disease neuroinflammation neurodegeneration FAU_Germany BrainBehavImm
By Dr. Priyom Bose, Ph.D.Sep 26 2022Reviewed by Benedette Cuffari, M.Sc. Parkinson’s disease is the second most common age-related neurodegenerative disease after Alzheimer’s disease . In a recent Brain, Behavior, and Immunity journal study, scientists reviewed in vitro and in vivo evidence associated with PD and leptin. More specifically, the current research focuses on the neuro-metabolic, neuro-immunomodulatory, and neurotrophic activity of leptin and other adipocytokines.
The prodromal stage of PD is characterized by hyposmia, constipation, and behavioral disorder. Aside from weight loss, PD patients also experience bone and muscle mass loss, which affects their mobility and increases the risk of falls and fractures. The role of leptin in brain development Leptin, primarily secreted by white adipose tissue, is an anorexigenic hormone linked to the hypothalamic regulation of food intake and body fat storage. The secretion of leptin depends on adipose tissue mass and provides negative feedback of bodily energy stores to the brain.
How does leptin influence PD? Genetics & Genomics eBook Compilation of the top interviews, articles, and news in the last year.Several studies have highlighted the role of leptin in the neuropathological and behavioral phenotype using a transgenic mouse model of AD. In the later stages of PD, most patients experience weight loss attributed to elevated energy expenditure. However, the exact underlying mechanism responsible for this weight loss remains unclear.
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