In a first, deep brain stimulation was used to measure uncontrollable, long-term pain in four people, opening a door to personalized care in the future.
reported that the rate of chronic pain in the US was as high as other common health issues like diabetes, depression, and high blood pressure.
Each participant underwent deep brain stimulation, a medical procedure that acts like a pacemaker for the cerebrum. The medical team implanted electrodes in specific areas to detect and record electrical activity from two brain regions associated with pain: the anterior cingulate cortex and the orbitofrontal cortex. The technique is commonly used for, but has never been tested with chronic pain.
Frontal x-ray image of one study participant, showing implanted brain recording electrodes connected to a bidirectional brain stimulating and recording implant on both sides.“This information can help drive more customized treatment options for patients,” Sharma says. “If we can objectively “see” the pain experience of a patient, then we can potentially modulate those areas of the brain with new interventions to alleviate or change the perception of pain.
The team learned that they couldn’t apply the same kinds of brain activity used to chart acute pain in therapeutic research to chronic pain in the real world. “Chronic pain is not a more enduring version of acute pain—it’s fundamentally different in the brain with different circuits,” Shirvalkar explains.
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