Treatment of primary progressive MS with DMTs for patients experiencing relapse or with disease activity is linked to a significant reduction of long-term disability risk, new research shows.
While a variety of DMTs are approved for the treatment of relapsing-remitting MS , randomized trials have generally not shown similar benefits among patients with PPMS ― which is why only ocrelizumab is currently approved for the indication.
The key characteristics associated with reaching the 7.0 or higher EDSS score included having a higher EDSS score at baseline , having relapses , and treatment with DMTs . While the link between relapse activity and improved outcomes may appear counterintuitive, such activity in patients who are receiving a DMT"cannot be compared with that occurring without treatment," the investigators note.
"Therefore, it would be crucial to identify, at the time of treatment introduction, patients who may experience persistent inflammatory activity in order to maximize the benefit-risk balance," they add.
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