Disruption of the blood-brain barrier due to long COVID researchsquare tcddublin COVID LongCOVID SARSCoV2 BloodBrainBarrier
By Bhavana KunkalikarJan 27 2023Reviewed by Aimee Molineux In a recent study posted to the Research Square* preprint server, researchers explored the destruction of the blood-brain barrier due to cognitive impairment associated with long coronavirus disease .
Eligible participants involved recovered COVID-19 patients, including persons aged 18 years and above who did or did not present neurological symptoms. Long COVID patients who reported the persistence of symptoms for over 12 weeks since infection were also eligible. The team collected serological specimens from 76 acute COVID-19 in-patients. Furthermore, 25 unaffected control specimens were obtained before the COVID-19 pandemic.
Related StoriesCOVID-19 severity which was assessed based on the World Health Organization Severity Guidelines revealed 25 unaffected patients along with ten moderate, 43 mild, and 23 severe cases. A remarkable increase in interleukin -8 levels was noted in moderate cases. Also, there was a considerable elevation in IL-6, IL-8, and tumor necrosis factor levels in severe COVID-19 cases.
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