Discovery of a potential new target for new MPOX or broad pox vaccines Antibodies Antigen Assay ELISA Enzyme Monkeypox Smallpox Vaccinia Virus MPOX medrxivpreprint UKHSA imperialcollege CDCgov
The MPXV outbreak in 2022 was primarily confined to gay, bisexual, and other men who had sex with men in non-endemic nations without a travel history to endemic areas. As a result, healthcare agencies and governments offered IMVANEX vaccinations to MPX patients to confer protection and curtail MPXV transmission.
Panels of sera obtained from single-dose, double-dose, and triple-dose ACAM2000 or IMVANEX vaccinees and individuals with MPX history were tested against the MPXV and VACV antigens. Pearson correlation analysis and PCA was performed, and ROC curves were used to elucidate humoral responses to MPXV and VACV infections.
Further, 256 pediatric serological samples were provided by the UKHSA SEU in Manchester. Confounder sera were obtained from individuals with polymerase chain reaction-confirmed cytomegalovirus infections , Epstein-Barr virus infections , and varicella-zoster virus infections with sera from Rheumatoid factor-positive individuals to evaluate specificity. ELISA was performed with individual antigens, followed by pooled antigen ELISA using MPXV antigens E8, B8, A35, B2, and VACV antigen B5.
MPXV patients and smallpox vaccinees mounted antibodies capable of binding to diverse albeit core poxviruses’ antigens, highlighting the implications for developing vaccine [such as mRNA -based vaccines] and treatment option [such as monoclonal antibodies ] targets.
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