Dietary recommendations for cardiovascular health challenged by new evidence on saturated fatty acids' effects on LDL-C and Lp(a) levels AJCNutrition cardiovascularhealth saturatedfattyacids fattyacids lipoprotein LDL cardiovascular CVD
By Dr. Chinta SidharthanMay 15 2023Reviewed by Lily Ramsey, LLM A recent perspective piece published in The American Journal of Clinical Nutrition discussed current dietary recommendations to reduce the intake of saturated fatty acids and modulate the risk of cardiovascular disease while highlighting the impact of lower saturated fatty acid intake on low-density lipoprotein cholesterol and lipoprotein A.
Furthermore, recent studies have found that while reduced saturated fatty acid intake lowers LDL-C levels, there is a subsequent increase in lipoprotein A levels following these dietary changes. Although lipoprotein A levels are primarily regulated by genetic factors, a few non-genetic factors that influence lipoprotein, A levels have been identified. These are broadly categorized as lipoprotein A-increasing and lipoprotein A-decreasing factors.
Various studies have shown that while replacing saturated fatty acids with carbohydrates or monounsaturated fatty acids does lower LDL-C levels, a subsequent increase in lipoprotein A levels increases. Furthermore, while reducing cardiovascular risk due to high LDL-C levels through the modulation of saturated fatty acid intake remains important, the clinical LDL-C measurements also include the cholesterol component from lipoprotein A.
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