A higher dose of magnesium each day keeps dementia at bay ANUmedia
the brain volumes including gray matter, white matter, left hippocampus, right hippocampus, and white matter lesions; andblood pressure including mean arterial pressure , systolic blood pressure , diastolic blood pressure , pulse pressure stratified by sexAssociations between baseline Mg, Mg trajectories, and brain volumes are presented in Table. Higher baseline Mg levels were strongly associated with larger brain volumes , with some variation across ROIs and sexes.
Two-way interactions between Mg and Mg trajectories as predictors of brain volumes and WMLs are presented in Tables S5, S7, and Fig. S3. No consistent pattern was detected but significant interactions were observed between baseline Mg, Mg trajectory, and GM, HC and WMLs, and more so in women than men. The “high-decreasing” trajectory was significantly associated with smaller GM and RHC and larger WMLs in women.
Also, a significant association between “high-decreasing” trajectory and PP was detected but only in women. Every 1 mg lower Mg below 350 mg/day was associated with a 1.51% increase PP in men, and a 7.4% increase PP in women. Table 4 Associations between baseline Mg, Mg trajectories and brain volumes and white matter lesions in pre- and post-menopausal womenHigher baseline Mg levels were more strongly associated with larger brain volumes after menopause . Every additional 1 mg Mg above 350 mg/day was associated with a 0.4% larger GM, 1.09% larger WM, 1.5% larger LHC, 1.4% RHC, and − 1.7% lower WMLs in post-menopausal compared to pre-menopausal women.
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