The Ottawa Ankle Rule can confidently predict ankle fractures when they exist with high sensitivity, reducing unnecessary radiographic referral – according to a systematic review and meta-analysis published in BMCMusculoSkeletDisord.
]. Also, our search strategy excluded non-English articles and conference abstracts, which could have influenced the results slightly. Thirdly, a potential source of heterogeneity is the threshold effect in meta-analyses. The spearman correlation coefficient in our analysis confirmed that there is no threshold effect related to heterogeneity; however, we reported a heterogenous effect across different studies with a Chi-square ranging from 81.7% to 99.7%.
This is surprising given its utilisation worldwide and the proliferation of research generally. This may be reflective of a much lower uptake than anticipated or a publication bias or other, unknown reasons. It does suggest, however, that further high-quality research in ongoing use of this tool is warranted.
Brasil Últimas Notícias, Brasil Manchetes
Similar News:Você também pode ler notícias semelhantes a esta que coletamos de outras fontes de notícias.
UK's EU law Bill could derail NI climate action because of burden on Stormont“The unnecessary risk of losing hundreds of essential standards and regulations is made all the more acute by the ongoing lack of functioning political institutions in Northern Ireland.”
Consulte Mais informação »
Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups - Nature GeneticsCross-disorder genetic association analyses identify five loci differentiating attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Individuals diagnosed with both ADHD and ASD are double-loaded with genetic risk for both disorders.
Consulte Mais informação »
Transparency and reporting characteristics of COVID-19 randomized controlled trials - BMC MedicineBackground In the context of the COVID-19 pandemic, randomized controlled trials (RCTs) are essential to support clinical decision-making. We aimed (1) to assess and compare the reporting characteristics of RCTs between preprints and peer-reviewed publications and (2) to assess whether reporting improves after the peer review process for all preprints subsequently published in peer-reviewed journals. Methods We searched the Cochrane COVID-19 Study Register and L·OVE COVID-19 platform to identify all reports of RCTs assessing pharmacological treatments of COVID-19, up to May 2021. We extracted indicators of transparency (e.g., trial registration, data sharing intentions) and assessed the completeness of reporting (i.e., some important CONSORT items, conflict of interest, ethical approval) using a standardized data extraction form. We also identified paired reports published in preprint and peer-reviewed publications. Results We identified 251 trial reports: 121 (48%) were first published in peer-reviewed journals, and 130 (52%) were first published as preprints. Transparency was poor. About half of trials were prospectively registered (n=140, 56%); 38% (n=95) made their full protocols available, and 29% (n=72) provided access to their statistical analysis plan report. A data sharing statement was reported in 68% (n=170) of the reports of which 91% stated their willingness to share. Completeness of reporting was low: only 32% (n=81) of trials completely defined the pre-specified primary outcome measures; 57% (n=143) reported the process of allocation concealment. Overall, 51% (n=127) adequately reported the results for the primary outcomes while only 14% (n=36) of trials adequately described harms. Primary outcome(s) reported in trial registries and published reports were inconsistent in 49% (n=104) of trials; of them, only 15% (n=16) disclosed outcome switching in the report. There were no major differences between preprints and peer-reviewed publications. Of the 130
Consulte Mais informação »
Upper Saxondale: Girl, 14, injured in hit-and-run crashThe girl suffered potentially life-altering injuries when she was hit by the car, police say.
Consulte Mais informação »