Fetal exposure to PCBs found to affect hearing health later in life beckmaninst sfnjournals
Exposure to combinations of environmental toxins is growing in prevalence, and therefore understanding their interactions is of increasing societal importance. Here, we examined the mechanisms by which two environmental toxins – polychlorinated biphenyls and high-amplitude acoustic noise – interact to produce dysfunction in central auditory processing. PCBs are well-established to impose negative developmental impacts on hearing.
These data suggest that combined PCBs and noise exposure act nonlinearly to damage hearing and that this damage is associated with synaptic reorganization, and reduced capacity to limit oxidative stress. In addition, this work provides a new paradigm by which to understand nonlinear interactions between combinations of environmental toxins.Exposure to common environmental toxins is a large and growing problem in the population.
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