Obituary: Remembering chemist David A. Evans (1941–2022)
David Evans discovered reactions that he applied to the synthesis of biologically active natural products as potential drug therapies, including antibiotics and anti-cancer agents. His contributions changed how researchers make complex natural molecules and design drugs. He has died, aged 81.
Evans was born in Washington DC. He earned a scholarship to Oberlin College, a small liberal-arts university in Ohio. There, the chemist Norman Craig engaged him in his research on small organic molecules. Evans forged a life-long friendship with Craig and remained dedicated to Oberlin. He often shared the story that he had cut the grass at the Craigs’ home one Saturday so that Craig could do some glass-blowing to make equipment for an experiment of mutual interest.
Evans began his doctoral studies at the University of Michigan in Ann Arbor and completed his PhD at the California Institute of Technology in Pasadena. He accepted his first faculty position in 1967 at the University of California, Los Angeles, later becoming a full professor. There, he began to study rearrangement reactions, in which the number and type of atoms remain the same, but their connectivity changes.
Evans’s last academic stop was at Harvard University in Cambridge, Massachusetts, where he was briefly chair of the chemistry department. His group revealed the full synthetic potential of the Evans auxiliary during this period, preparing numerous complex natural products. They also made major contributions to asymmetric catalysis. These syntheses tackled thorny assemblies of stereochemically complex components.
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