More than 40% of athletes exposed to repetitive head impacts had CTE, even those who only played in youth, high school, or college sports.
More than 95% had mild CTE. Diagnosis was associated with older age and significantly more years of exposure to contact sports .
"We don't have enough brain donations to make any comments about differences between the genders, but we've always known that women can develop CTE," she said."It's been reported after domestic violence and in an autistic woman who was a headbanger, so it was just a matter of time before we found our first case."Neuropathological analysis revealed neuronal p-tau aggregates in all CTE cases, a hallmark of the disease.
Investigators also found evidence of perivascular macrophages in the deep white matter, a microscopic change that correlated with CTE and years of play and indicates a breach of the blood–brain barrier which could allow pro-inflammatory molecules to enter the brain, setting up a neuroinflammatory response.
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