From inside humans to the International Space Station, the popular gene-editor is pushing new boundaries.
This article appeared in the January/February 2022 issue ofThe CRISPR-Cas9 gene-editing tool once again ventured into uncharted territory this past year — in more ways than one.
By knocking out the malfunctioning TTR gene, the researchers hoped to halt the production of harmful proteins and effectively stop the disease in its tracks. They accomplished this by injecting the CRISPR gene editor — encased in a lipid nanoparticle carrying a piece of RNA to serve as a guide to the TTR gene — into the patients’ bodies. The trial marks one of the first times scientists used CRISPR directly inside the body.
NASA astronaut Christina Koch uses CRISPR to generate and repair DNA breaks in yeast cells in microgravity.
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