Using whole genome sequencing, a new Lancet Microbe study sheds light on syphilis transmission dynamics in England. The research identifies distinct transmission clusters, revealing the effectiveness of genomic data in tracking and intervening in syphilis outbreaks.
By Dr. Priyom Bose, Ph.D.Sep 20 2023Reviewed by Benedette Cuffari, M.Sc. A recent Lancet Microbe study used whole genome sequencing to gain epidemiological insights into syphilis transmission.
An increase in syphilis has also been recorded in heterosexual men and women, which indicates the possibility of vertical transmission causing congenital syphilis. Between 2015 and 2020, about 24 cases of congenital syphilis have been identified in England. In some regions of England, an increase in syphilis cases was recorded among women and GBMSM, thus indicating an overlapping sexual network as the underlying cause for broader dissemination.
About the study The current study used WGS to understand the transmission dynamics of syphilis at national and regional levels. T. pallidum-positive genomic DNA samples were obtained from the United Kingdom Health Security Agency , London, and five laboratories that perform in-house molecular T. pallidum diagnostic testing.
A total of 497 samples were identified between January 1, 2012, and October 31, 2018, that were considered suitable for WGS. Of these samples, complete genomes of 240 samples were recovered, 220 of which were ultimately considered for the analysis.
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