Hamsters eating Cocoa Krispies reveal inflammation pathways from the olfactory system to the brain.
An impaired sense of smell affects from about 30 to 75 percent of people infected with the novel coronavirus, according to a recent estimate, suggesting that millions of people worldwide have suffered this condition at some point in the past two years. Called anosmia, the olfactory system dysfunction is typically temporary, but it can take months or longer for a full recovery, making it difficult to enjoy meals and to detect odors such as spoiled food, smoke and others that can signal danger.
There has yet to be any biology witnessed in manifestations of COVID-19 in humans that we cannot replicate in hamsters. So we studied three groups of hamsters—a group infected with SARS-CoV-2, a group that received a control substance as a mock infection and an influenza-infected group to provide a benchmark showing the typical immune response to a common respiratory virus.
The cells are still there, and the cells aren’t dying. They are just busy doing something else. And as a result, you will lose your sense of smell, because so much bandwidth has been taken away, and your olfactory machinery can no longer comprehend such a complex process. And so, for a brief period of time, about three to five days after infection with SARS-CoV-2, many people lose their sense of smell.
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