New method allows scientists to determine all the molecules present in the lysosomes of mice nature
Extended Data Fig. 3 Validation of glycerophosphodiesters as the metabolites that accumulate in lysosomes upon CLN3 loss., Identification and annotation of metabolites using untargeted metabolomics analyses. Overview of our untargeted metabolomics experimental workflow. MS1 data were collected for every sample using full scan mode on a high-resolution accurate-mass instrument. MS/MS data were collected from pooled samples only to aid with compound identification.
Compounds which were statistically significant in the differential analyses were validated and identified using authentic standards, when available. If no authentic standard was available, compounds were annotated by comparing MS/MS data to a database, orfragmentation prediction . Data were then reported according to the Metabolomics Standards Initiative guidelines., Mirror plots for GPC and GPI in negative ion mode, respectively.
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