According to health data firm Airfinity, more than 5,000 people are probably dying each day from COVID-19 in China, with the firm’s mortality risk analysis suggesting that 1.3 to 2.1 million people could die in the country’s current COVID outbreak.
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Longitudinal transcriptional analysis of peripheral blood leukocytes in COVID-19 convalescent donors - Journal of Translational MedicineBackground SARS-CoV2 can induce a strong host immune response. Many studies have evaluated antibody response following SARS-CoV2 infections. This study investigated the immune response and T cell receptor diversity in people who had recovered from SARS-CoV2 infection (COVID-19). Methods Using the nCounter platform, we compared transcriptomic profiles of 162 COVID-19 convalescent donors (CCD) and 40 healthy donors (HD). 69 of the 162 CCDs had two or more time points sampled. Results After eliminating the effects of demographic factors, we found extensive differential gene expression up to 241 days into the convalescent period. The differentially expressed genes were involved in several pathways, including virus-host interaction, interleukin and JAK-STAT signaling, T-cell co-stimulation, and immune exhaustion. A subset of 21 CCD samples was found to be highly “perturbed,” characterized by overexpression of PLAU, IL1B, NFKB1, PLEK, LCP2, IRF3, MTOR, IL18BP, RACK1, TGFB1, and others. In addition, one of the clusters, P1 (n = 8) CCD samples, showed enhanced TCR diversity in 7 VJ pairs (TRAV9.1_TCRVA_014.1, TRBV6.8_TCRVB_016.1, TRAV7_TCRVA_008.1, TRGV9_ENST00000444775.1, TRAV18_TCRVA_026.1, TRGV4_ENST00000390345.1, TRAV11_TCRVA_017.1). Multiplexed cytokine analysis revealed anomalies in SCF, SCGF-b, and MCP-1 expression in this subset. Conclusions Persistent alterations in inflammatory pathways and T-cell activation/exhaustion markers for months after active infection may help shed light on the pathophysiology of a prolonged post-viral syndrome observed following recovery from COVID-19 infection. Future studies may inform the ability to identify druggable targets involving these pathways to mitigate the long-term effects of COVID-19 infection. Trial Registration: https://clinicaltrials.gov/ct2/show/NCT04360278 Registered April 24, 2020.
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Is Everyone Sick Right Now? Boston Doctors Talk the Cold, Flu, RSV, COVIDBoston doctors say there are plenty of other viruses circulating that are causing people to be under the weather. Here's what to know:
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History of COVID-19 increases risk of fatigue and other long COVID symptoms in adults and childrenHistory of COVID-19 increases risk of fatigue and other long COVID symptoms in adults and children Children Coronavirus Disease COVID Fatigue medrxivpreprint WeillCornell CDCgov LPHIorg harvardmed
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Since Covid, my Christmas dinner tastes like mouldThousands of people who had coronavirus face yet another Christmas with the smell disorder parosmia.
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Fleeing China's Covid lockdowns for the US - through a Central American jungleFed up with lockdowns and Xi's policies, some Chinese citizens are taking a perilous journey to escape.
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Dutch study shows the effectiveness of COVID vaccination in reducing hospitalizationsThe study, which is currently available in the medRxiv* preprint server, reveals that the COVID-19 vaccination has prevented a large number of hospitalizations during the pandemic.
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