Chances of eliminating HIVinfection increased by novel dual gene-editing approach TempleUniv PNASNews
Gene-editing therapy aimed at two targets—HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that helps the virus get into cells—can effectively eliminate HIV infection, new research from the Lewis Katz School of Medicine at Temple University and the University of Nebraska Medical Center shows. The study, published online in the journal, is the first to combine a dual gene-editing strategy with antiretroviral drugs to cure animals of HIV-1.
"We are true partners, and what we achieved here is really spectacular," Dr. Gendelman said."Dr. Khalili's team generated the essential gene-editing constructs, and we then applied those constructs in our LASER-ART mouse model at Nebraska, figuring out when to administer gene-editing therapy and carrying out analyses to maximize HIV-1 excision, CCR5 inactivation, and suppression of viral growth.
To prevent rebound infection, Dr. Khalili and colleagues began work on next-generation CRISPR technology for HIV excision, developing a new, dual system aimed at permanently eliminating HIV from the animal model."From success stories of human HIV patients who have undergone bone marrow transplantation for leukemia and been cured of HIV, our hypothesis was that the loss of the virus's receptor, CCR5, is important to permanently eliminating HIV infection," he explained.
Brasil Últimas Notícias, Brasil Manchetes
Similar News:Você também pode ler notícias semelhantes a esta que coletamos de outras fontes de notícias.
Ron DeSantis’s lurch in Florida hurts his presidential chancesAn abrupt shift to the right was meant to showcase the governor’s conservative credentials. Instead it has provoked concern
Consulte Mais informação »
Premier League most chances created: Trippier takes the lead over De Bruyne and BrunoAll hail Kieran Trippier, the new king of chances created. The full-back is now five clear of De Bruyne and Bruno Fernandes as Newcastle storm towards the Champions League.
Consulte Mais informação »
Ron DeSantis’s rightward lurch hurts his presidential chancesAlthough he has not yet announced his run, Ron DeSantis is using Florida as a stage to project his “Florida blueprint” for the rest of the country
Consulte Mais informação »
Scots AI expert predicts 'chatbots' will soon be marking university essaysAbertay University Principal Professor Liz Bacon warns that all Scots should accept that chatbots like ChatGPT will be a part of daily life within a year.
Consulte Mais informação »
Maurizio Cattelan: Banana artwork eaten by Seoul museum visitorA university student told staff he ate the fruit on display because he was hungry.
Consulte Mais informação »