As part of the biggest omics study of its type, researchers at the University College London and the University of Southampton discovered that cervical cancer may be separated into two different molecular subgroups, one significantly more dangerous than the other. The groundbreaking discoveries,
, derived molecular profiles and looked at clinical outcomes of a further 313 CSCC cases held in Norway and Austria, for which much more detailed patient follow-up data were available.
Next, by analyzing a further cohort of 94 Ugandan CSCC cases, the team found that C2 tumors were much more common than C1 tumors in patients who were also HIV-positive, underlining the link to a weaker anti-tumor immune response in this group. “Given the differences in the anti-tumor immune response observed in C1 and C2 tumors, this classification might also be useful in predicting which patients are likely to benefit from emerging immunotherapy drugs such as pembrolizumab , but C1/C2 typing will need to be incorporated into clinical trials to test this.”
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