New research suggests that a vaccine for tuberculosis that's been around for a century might work dramatically better if it is injected straight into the bloodstream rather than under the skin.
This image provided by the University of Pittsburgh School of Medicine and the National Institute of Allergy and Infectious Diseases shows a collection of lung scans of 20 monkeys who were exposed to tuberculosis after receiving different forms of a TB vaccine. Monkeys in the top row received skin-deep shots, and those in the bottom row were given intravenous injections. The intravenous vaccine protected far better, as shown by TB-caused inflammation seen in red and yellow.
In a study with monkeys, injecting the vaccine straight into the bloodstream dramatically improved its effectiveness over today’s skin-deep shot, researchers reported Wednesday. Most vaccines are shots jabbed in the muscle or skin. Seder came up with the idea of IV immunization a few years ago, with experiments showing a malaria vaccine candidate worked better when injected into a vein. He wondered if the TB vaccine would react the same way.
But in 9 of 10 monkeys, a higher-than-usual vaccine dose injected into a vein worked much better, the researchers reported in the journal Nature. The team found no trace of infection in six of the animals and counted very low levels of TB bacteria in the lungs of three.
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