The CDC is recommending that people who have received two shots of a Covid-19 vaccine produced by Johnson & Johnson and Janssen follow up with a booster of one of the FDA-approved mRNA vaccines from Pfizer-BioNTech and Moderna.
that people who have received two shots of a Covid-19 vaccine produced by Johnson & Johnson and Janssen follow up with a booster of one of the FDA-approved mRNA vaccines from Pfizer-BioNTech and Moderna, which could produce a stronger immune response and lessen the risk of rare but severe side effects.
The researchers also found that two Johnson & Johnson doses was 67% effective at preventing hospitalization, compared to 78% after one Johnson & Johnson dose and one dose of either of the mRNA vaccines, based on data from 25,244 hospitalizations among patients with Covid-like illness. The CDC’s recommendation that patients mix and match vaccine types was also informed by data associating Johnson & Johnson’s vaccine with rare but severe side effects like thrombosis—when clots block blood vessels—and Guillain-Barré syndrome—an immune disorder that can cause paralysis.
Though little data has been gathered about the effects of mixing Johnson & Johnson shots with Pfizer or Moderna’s, the new study reinforces findings from a previous cohort study of U.S. veterans that provisionally indicated that one Johnson & Johnson shot and one shot from Pfizer or Moderna gave better protection against the omicron variant of the coronavirus than two Johnson & Johnson shots, the CDC said.of Americans in that age group have been boosted so far, including 67.
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